New Publication
- christophkleber
- 20 hours ago
- 1 min read
New Publication by Roger Hasler and Jakub Dostalek from LiST DPU together with colleagues from BioMed X Institute (Heidelberg, Germany), N&MH-Neuroscience and Mental Health, Boehringer Ingelheim Pharma GmbH & Co. KG (Biberach an der Riß, Germany), and School of Biological and Health Systems Engineering, Arizona State University (Arizona, United States), titled “Aptagel Plasmonic Fiber Optic Biosensor for In Vivo Continuous Drug Monitoring”.
Our research demonstrates the first implantable plasmonic fiber optic biosensor for continuous, label-free monitoring of a small-molecule drug directly in living brain tissue. By combining a miniaturized fiber optic surface plasmon resonance (FO-SPR) probe with a molecularly responsive aptagel hydrogel, we achieved real-time tracking of the antibiotic vancomycin in the rat brain with a temporal resolution of approximately 3 seconds. This proof-of-concept study shows that plasmonic fiber-based biosensors can operate in the complex in vivo environment, opening new opportunities for continuous pharmacokinetic monitoring, precision medicine, and future implantable biosensing technologies for deep-tissue applications.
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